Seminar: Cardiac Biomarker Estimation in Anorexia Nervosa 2.0

Adolescent girls with AN undergo high levels of stress, which has been shown as risk factor in the development of eating disorders. Widely examined autonomic indices for stress reactivity are heart rate (HR) and heart rate variability (HRV, RR intervals (RRI) in electrocardiogram). The current state of the art concerning HRV as a biomarker for AN show consistently elevated beat-by-beat variance for AN compared to controls. Thus, HRV features may act as a discriminating biomarker and may be used as input feature to different AI methods.

Aim

In a pilot study, in cooperation with the University Hospital Erlangen (Department of Child and Adolescent Psychiatry), we will estimate possible biomarkers from HRV measurements in the course of a body confrontation intervention and a whole therapy block (3-4 interventions) in AN patients. For this purpose, an existing pipeline will be extended, which will further refine previous results and thus provide information on stress reactivity in relation to potentially stressful situations alias body confrontations.

Learning Objectives

• Learn concepts of HRV analysis
• Develop corresponding algorithms
• Apply biomarker estimations

Data

Literature

Literature recommendations are provided during the meetings. The candidate is further encouraged to research relevant publications on this topic.

Examination

Final presentation and final report

Contact

Lena Uhlenberg

• Job title: Researcher
• Address:
  
  Henkestraße 91, Haus 7, 1. OG
  91052 Erlangen
  Germany
• Phone number: +49 9131 85-23605
• Email: lena.uhlenberg@fau.de

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